Management of hepatitis B during pregnancy

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Hepatitis B in pregnancy

OBJECTIVE Vertical transmission of the hepatitis B virus (HBV) is the commonest mode of infection and can be prevented with immunoprophylaxis of the infant and antiviral therapy in the mother. Our aim was to review a cohort of subjects with HBV in pregnancy to determine the prevalence of active disease or high HBV-DNA levels that required treatment to prevent transmission, and to review the man...

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Clinical course of hepatitis B virus infection during pregnancy.

BACKGROUND For women with hepatitis B virus (HBV) infection, little is known about the natural progression of the disease during pregnancy or its impact on pregnancy outcomes. OBJECTIVES To investigate the natural progression of HBV infection during pregnancy or its impact on pregnancy outcomes. METHODS In this retrospective cohort study, we reviewed medical records of all patients who were...

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Hepatitis B Virus Infection during Pregnancy: Transmission and Prevention

Hepatitis B virus (HBV) infection is a global public health problem. In endemic areas, HBV infection occurs mainly during infancy and early childhood, with mother to child transmission (MTCT) accounting for approximately half of the transmission routes of chronic HBV infections. Prevention of MTCT is an essential step in reducing the global burden of chronic HBV. Natal transmission accounts for...

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Cytomegalovirus Hepatitis During Pregnancy

BACKGROUND Although cytomegalovirus (CMV) is an uncommon cause of viral hepatitis during pregnancy, a definitive diagnosis is important because of the potential for congenital CMV. In the case reported here, a diagnosis of hepatitis caused by CMV was made after the more common viral pathogens had been ruled out. CASE A 17-year-old, 12-week pregnant patient was evaluated for fever and right up...

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Hepatitis B Therapy in Pregnancy

All decisions about initiating, continuing, or stopping therapy of the hepatitis B virus (HBV) during pregnancy must include an analysis of the risks and benefits for mother and fetus. The trimester of the pregnancy and the stage of the mother's liver disease are important factors. Treatment in the third trimester may be initiated to aid in preventing perinatal transmission, which appears to be...

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ژورنال

عنوان ژورنال: Nature Reviews Gastroenterology & Hepatology

سال: 2014

ISSN: 1759-5045,1759-5053

DOI: 10.1038/nrgastro.2014.30